Research Paper Volume 13, Issue 6 pp 8320—8334

Celecoxib alleviates zinc deficiency-promoted colon tumorigenesis through suppressing inflammation

Celecoxib attenuated ZD-promoted colon tumorigenesis through suppressing pro-inflammatory mediators. (A) Effect of celecoxib on tumor number (n=15). (B) Effect of celecoxib on tumor incidence (n=15). (C) Effect of celecoxib on mRNA expression of IL1β, IL6, CCL2, CXCL2, and CXCL5 (n=6). (D) Effect of celecoxib on protein level of IL1β and CXCL5 (n=6). Data are showed as means ±SEM. *P P P #P ##P

Figure 6. Celecoxib attenuated ZD-promoted colon tumorigenesis through suppressing pro-inflammatory mediators. (A) Effect of celecoxib on tumor number (n=15). (B) Effect of celecoxib on tumor incidence (n=15). (C) Effect of celecoxib on mRNA expression of IL1β, IL6, CCL2, CXCL2, and CXCL5 (n=6). (D) Effect of celecoxib on protein level of IL1β and CXCL5 (n=6). Data are showed as means ±SEM. *P < 0.05, **P < 0.01 and *** P < 0.001 vs ZS groups. #P < 0.05 and ##P < 0.01 vs ZD + celecoxib group.