Research Paper Volume 13, Issue 6 pp 8454—8466

Endogenous conversion of n-6 to n-3 polyunsaturated fatty acids facilitates the repair of cardiotoxin-induced skeletal muscle injury in fat-1 mice

High endogenous n-3 PUFA levels increase muscle regenerative capacity in response to cardiotoxin-induced skeletal muscle injury in fat-1 mice. Representative immunofluorescence images and quantitative analysis shows the expression levels of (A, B) PAX-7 and (C, D) MyoD proteins in the gastrocnemius muscle tissues from Fat-1 and wild-type mice on day 3 after CTX-induced muscle injury. Scale bar = 20 μm. Data were expressed as the mean ± SD (n = 4-5). NS, non-significant; ** P

Figure 6. High endogenous n-3 PUFA levels increase muscle regenerative capacity in response to cardiotoxin-induced skeletal muscle injury in fat-1 mice. Representative immunofluorescence images and quantitative analysis shows the expression levels of (A, B) PAX-7 and (C, D) MyoD proteins in the gastrocnemius muscle tissues from Fat-1 and wild-type mice on day 3 after CTX-induced muscle injury. Scale bar = 20 μm. Data were expressed as the mean ± SD (n = 4-5). NS, non-significant; ** P < 0.01 vs. WT.