Research Paper Volume 13, Issue 5 pp 7608—7626

MiR-452-5p promotes colorectal cancer progression by regulating an ERK/MAPK positive feedback loop

The up-regulation of miR-452-5p in CRC. (A) Bioinformatics analysis of miR-452-5p expression levels in colorectal cancer (T, n=619) and normal colorectal tissue (N, n=11) in TCGA database. (B) The expression levels of miR-452-5p in colorectal cancer tissues (T, n=87) and adjacent normal tissues (N, n=87) were detected by real-time quantitative PCR. (C) Waterfall plot showed the relative levels of miR-452-5p expression in colorectal cancer (T, n=87) and normal adjacent tissues (N, n=87).*p

Figure 1. The up-regulation of miR-452-5p in CRC. (A) Bioinformatics analysis of miR-452-5p expression levels in colorectal cancer (T, n=619) and normal colorectal tissue (N, n=11) in TCGA database. (B) The expression levels of miR-452-5p in colorectal cancer tissues (T, n=87) and adjacent normal tissues (N, n=87) were detected by real-time quantitative PCR. (C) Waterfall plot showed the relative levels of miR-452-5p expression in colorectal cancer (T, n=87) and normal adjacent tissues (N, n=87).*p < 0.05, **p < 0.01, ***p < 0.001.