Research Paper Volume 13, Issue 5 pp 7608—7626

MiR-452-5p promotes colorectal cancer progression by regulating an ERK/MAPK positive feedback loop

PKN2/DUSP6 axis is involved in the miR-452-5p regulation of CRC cells biological behaviors. (A) PKN2 and DUSP6 were verified to be involved in the regulation of miR-452-5p on colorectal cancer cell proliferation: panel cloning assay. (B) CCK8 assays showed that PKN2/DUSP6 reversed cell proliferation induced by miR-452-5p. (C) PKN2, DUSP6 were verified to be involved in the regulation of miR-452-5p on CRC cell apoptosis. (D) PKN2/DUSP6 axis was involved in the regulation of miR-452-5p on the important CRC signaling pathways.*p

Figure 5. PKN2/DUSP6 axis is involved in the miR-452-5p regulation of CRC cells biological behaviors. (A) PKN2 and DUSP6 were verified to be involved in the regulation of miR-452-5p on colorectal cancer cell proliferation: panel cloning assay. (B) CCK8 assays showed that PKN2/DUSP6 reversed cell proliferation induced by miR-452-5p. (C) PKN2, DUSP6 were verified to be involved in the regulation of miR-452-5p on CRC cell apoptosis. (D) PKN2/DUSP6 axis was involved in the regulation of miR-452-5p on the important CRC signaling pathways.*p < 0.05, **p < 0.01, ***p < 0.001.