Priority Research Paper Volume 13, Issue 4 pp 4747—4777

Insights into epithelial cell senescence from transcriptome and secretome analysis of human oral keratinocytes

Top 100 Upregulated and Downregulated Genes. (A) Top 100 upregulated genes. These include those coding for proteins with functions in inflammation, proteases, protease inhibitors, and genes implicated in cancer. (B) Top 100 downregulated genes. These include 52 genes upregulated in at least one type of cancer (ID4, PDCL2, ADH7, BGN, GABRQ, NMU, LCE2B, LOR, FABP12, CACNG4, KRT4, TRPV6, TMEM45B, SERPINB11, ARG1, LGALS7, NKX2-3, NR4A1, KRT1, NGEF, UNC5B-AS1, MIR675, KRTDAP, KRT13, TMEM56, LINC00592, KLK14, KRT80, TMPRSS11A, OCLN, HORMAD1, PREX2, TPPP3, CLCA1, FOSB, DAPL1, LRRN4CL, IGSF9B, SLC27A2, WNT10A, NUP210, KRT10, LINC01512, CYP2C18, TMPRSS4, INHBE, SAPCD2, PTGER3, SLC44A4, CALCB, PIK3AP1, AQP3).

Figure 2. Top 100 Upregulated and Downregulated Genes. (A) Top 100 upregulated genes. These include those coding for proteins with functions in inflammation, proteases, protease inhibitors, and genes implicated in cancer. (B) Top 100 downregulated genes. These include 52 genes upregulated in at least one type of cancer (ID4, PDCL2, ADH7, BGN, GABRQ, NMU, LCE2B, LOR, FABP12, CACNG4, KRT4, TRPV6, TMEM45B, SERPINB11, ARG1, LGALS7, NKX2-3, NR4A1, KRT1, NGEF, UNC5B-AS1, MIR675, KRTDAP, KRT13, TMEM56, LINC00592, KLK14, KRT80, TMPRSS11A, OCLN, HORMAD1, PREX2, TPPP3, CLCA1, FOSB, DAPL1, LRRN4CL, IGSF9B, SLC27A2, WNT10A, NUP210, KRT10, LINC01512, CYP2C18, TMPRSS4, INHBE, SAPCD2, PTGER3, SLC44A4, CALCB, PIK3AP1, AQP3).