Research Paper Volume 13, Issue 5 pp 7627—7643

Nicotine exacerbates atherosclerosis through a macrophage-mediated endothelial injury pathway

Smoking aggravates the Gensini score, TXNIP expression, and cytokine secretion in patients with CHD. (A) The Gensini score was evaluated in every patient based on the results of coronary angiography. (B) TXNIP mRNA expression was measured in the monocytes of CHD patients. (C) Correlation analysis of Gensini score and TXNIP expression. (D) IL-1β and IL-18 from plasma in patients with CHD were analyzed. The smoking groups were compared to the non-smoking groups (*P

Figure 1. Smoking aggravates the Gensini score, TXNIP expression, and cytokine secretion in patients with CHD. (A) The Gensini score was evaluated in every patient based on the results of coronary angiography. (B) TXNIP mRNA expression was measured in the monocytes of CHD patients. (C) Correlation analysis of Gensini score and TXNIP expression. (D) IL-1β and IL-18 from plasma in patients with CHD were analyzed. The smoking groups were compared to the non-smoking groups (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001).