Research Paper Volume 13, Issue 5 pp 7627—7643

Nicotine exacerbates atherosclerosis through a macrophage-mediated endothelial injury pathway

Nicotine enhances macrophage chemotaxis and TXNIP expression in plaque. (A, B) Triple immunofluorescence for CD68, TXNIP, and CD31 was used to analyze macrophage chemotaxis, TXNIP expression in vascular wall tissues, and vascular endothelium integrity, respectively, and their connection in the plaque of brachiocephalic trunk cross-sections (*P

Figure 6. Nicotine enhances macrophage chemotaxis and TXNIP expression in plaque. (A, B) Triple immunofluorescence for CD68, TXNIP, and CD31 was used to analyze macrophage chemotaxis, TXNIP expression in vascular wall tissues, and vascular endothelium integrity, respectively, and their connection in the plaque of brachiocephalic trunk cross-sections (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, n=5).