Research Paper Volume 13, Issue 5 pp 7644—7659

Platelets transport β-amyloid from the peripheral blood into the brain by destroying the blood-brain barrier to accelerate the process of Alzheimer's disease in mouse models

Effects of plasma or platelets from aged mice on spatial learning and memory abilities. (A) Latency (escape latency), the time the mice spent finding the underwater hidden platform on the MWM training days. (B) Crossing times, the number of times the mice crossed the former platform area during the probe trial on the last day. (C) Track trail, the track trail of the mice during the probe trial on the last day. (D) Time spent in the target quadrant. (E) Average speed, average swimming speed of the mice per day, showing that the experimental results, such as latency, are not related to the swimming speed of the mice. Each group contained 8 mice. *P#P##P###P

Figure 3. Effects of plasma or platelets from aged mice on spatial learning and memory abilities. (A) Latency (escape latency), the time the mice spent finding the underwater hidden platform on the MWM training days. (B) Crossing times, the number of times the mice crossed the former platform area during the probe trial on the last day. (C) Track trail, the track trail of the mice during the probe trial on the last day. (D) Time spent in the target quadrant. (E) Average speed, average swimming speed of the mice per day, showing that the experimental results, such as latency, are not related to the swimming speed of the mice. Each group contained 8 mice. *P<0.05 compared with C57+NS; #P<0.05, ##P<0.01, and ###P<0.001, compared with C57+APP/PS1 platelets.