Research Paper Volume 13, Issue 5 pp 7644—7659

Platelets transport β-amyloid from the peripheral blood into the brain by destroying the blood-brain barrier to accelerate the process of Alzheimer's disease in mouse models

Effects of tail vein injection of plasma or platelets on AD related indexes of blood and brain tissue in mice. (E) Brain image of a C57+APP/PS1 platelet mouse by MRI. (F) Quantity of platelets. (G) Volume of platelets. Each group included 8 mice. No significant differences were observed between groups. (H) Aβ1-40, Aβ1-42 and tau protein levels per unit of platelets. (I) Aβ1-40 levels in platelets. (J) Aβ1-42 levels in platelets. (K) Tau levels in platelets. Each group included 8 mice. *P#P

Figure 4. Effects of tail vein injection of plasma or platelets on AD related indexes of blood and brain tissue in mice. (E) Brain image of a C57+APP/PS1 platelet mouse by MRI. (F) Quantity of platelets. (G) Volume of platelets. Each group included 8 mice. No significant differences were observed between groups. (H) Aβ1-40, Aβ1-42 and tau protein levels per unit of platelets. (I) Aβ1-40 levels in platelets. (J) Aβ1-42 levels in platelets. (K) Tau levels in platelets. Each group included 8 mice. *P<0.05 compared with C57+NS and #P<0.05 compared with C57+APP/PS1 platelets.