Research Paper Volume 13, Issue 6 pp 8541—8562

TACC3 is a prognostic biomarker for kidney renal clear cell carcinoma and correlates with immune cell infiltration and T cell exhaustion

Correlations between T cells exhaustion-associated markers and TACC3 expression. (A) GZMB, (B) LAG-3, (C) PD-1, (D) TM3, (E) TGFβ1, (F) PDL1, (G) CCR8, (H) CTLA4, (I) FOXP3. The blue and red violins represent T cells-exhaustion associated markers in low and high TACC3 expressing groups, respectively. All these markers showed significant differences between TACC3 high and low expressing groups. The solid lines represent median expressions of infiltrated cells and the dotted lines represent quartiles. * p

Figure 7. Correlations between T cells exhaustion-associated markers and TACC3 expression. (A) GZMB, (B) LAG-3, (C) PD-1, (D) TM3, (E) TGFβ1, (F) PDL1, (G) CCR8, (H) CTLA4, (I) FOXP3. The blue and red violins represent T cells-exhaustion associated markers in low and high TACC3 expressing groups, respectively. All these markers showed significant differences between TACC3 high and low expressing groups. The solid lines represent median expressions of infiltrated cells and the dotted lines represent quartiles. * p<0.05, ** p<0.01, *** p<0.001.