Research Paper Volume 13, Issue 6 pp 8588—8598

Inhibition of complement C5a receptor protects lung cells and tissues against lipopolysaccharide-induced injury via blocking pyroptosis

Alterations of histological evaluation, lung wet/dry ratio, BALF cell counts and total protein level. (A) Morphological changes in the lung by H&E staining. The sections were stained with hematoxylin (blue, nucleus) and eosin (pink, muscle fiber). The scale bar represents 50 μm. (B) Morphological changes in the lung by Periodic Acid Schiff (PAS) staining. The sections were stained with hematoxylin (blue, nucleus) and PAS (pink, glycogen). The scale bar represents 50 μm. (C–E) Effect of W-54011 on lung wet/dry ratio (C), BALF cell counts (D) and total protein level (E) 12 h after intratracheal instillation of LPS. n = 7. *P **P ***P

Figure 1. Alterations of histological evaluation, lung wet/dry ratio, BALF cell counts and total protein level. (A) Morphological changes in the lung by H&E staining. The sections were stained with hematoxylin (blue, nucleus) and eosin (pink, muscle fiber). The scale bar represents 50 μm. (B) Morphological changes in the lung by Periodic Acid Schiff (PAS) staining. The sections were stained with hematoxylin (blue, nucleus) and PAS (pink, glycogen). The scale bar represents 50 μm. (CE) Effect of W-54011 on lung wet/dry ratio (C), BALF cell counts (D) and total protein level (E) 12 h after intratracheal instillation of LPS. n = 7. *P < 0.05, **P < 0.01 and ***P < 0.001.