Research Paper Volume 13, Issue 6 pp 8643—8664

Follistatin-like protein 1 functions as a potential target of gene therapy in proliferative diabetic retinopathy

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Figure 12.

The expression of FSTL1, TGFβ1, CTGF, VEGF, FN, COL1, and α-SMA mRNA in FSTL1 overexpression group and FSTL1 knockdown group. (AG) indicates that the FSTL1 and ECM-related mRNA expression in the blank control group (N), negative control group (NC), FSTL1 overexpression group (Overexpression) and FSTL1 siRNA group (Knockdown) respectively. The expression of FSTL1, TGFβ1, CTGF, VEGF, FN, COL1, and α-SMA mRNA were all upregulated in FSTL1 overexpression group compared with negative control group, and were all downregulated in the FSTL1 knockdown group (N: blank control group, NC: negative control group compared with negative control group, Overexpression: FSTL1 overexpression group, Knockdown: FSTL1 siRNA group). Data are expressed as mean ± SEM. * P < 0.05, ** P < 0.01, *** P < 0.001.