Research Paper Volume 13, Issue 6 pp 8665—8687

MicroRNA-95-3p serves as a contributor to cisplatin resistance in human gastric cancer cells by targeting EMP1/PI3K/AKT signaling

MiR-95-3p is a pathologic gene in DDP-resistant GC. (A) Volcano plot of the correlated gene of DDP-resistant SGC7901. (B) Heat map of DDP-resistant GC target gene. (C) Results from qRT-PCR indicated that miR-95-3p is overexpressed in DDP-resistant GC tissues compared to DDP-sensitive GC tissues. (D) qRT-PCR results indicated that miR-95-3p is highly expressed in DDP-resistant GC cell line. (E) qRT-PCR results indicated that expression of miR-95-3p is higher in gastric cancer tissues compared to paracancer tissues. (F) Low expression of miR-95-3p is associated with higher survival rate in gastric cancer patients. ***p

Figure 2. MiR-95-3p is a pathologic gene in DDP-resistant GC. (A) Volcano plot of the correlated gene of DDP-resistant SGC7901. (B) Heat map of DDP-resistant GC target gene. (C) Results from qRT-PCR indicated that miR-95-3p is overexpressed in DDP-resistant GC tissues compared to DDP-sensitive GC tissues. (D) qRT-PCR results indicated that miR-95-3p is highly expressed in DDP-resistant GC cell line. (E) qRT-PCR results indicated that expression of miR-95-3p is higher in gastric cancer tissues compared to paracancer tissues. (F) Low expression of miR-95-3p is associated with higher survival rate in gastric cancer patients. ***p<0.001, **p<0.01 compared to parental SGC7901.