Research Paper Volume 13, Issue 6 pp 8688—8705

Establishment and validation of an eight-gene metabolic–related prognostic signature model for lung adenocarcinoma

Construction of a prognostic gene signature. (A) Hazard ratio and p values of the selected candidate genes. (B) Heatmap showing the expression profiles of the selected candidate genes. (C–D) LASSO cox regression identified eight signature genes that were most correlated with OS. These genes were used to construct a signature model. (E) The coefficient value of the selected eight signature genes. (F) Expression correlation analysis of the eight signature genes. (G) The expression profiles of the eight signature genes in tumor and cancer samples. (H) Mutation landscape of the eight signature genes in LUAD.

Figure 4. Construction of a prognostic gene signature. (A) Hazard ratio and p values of the selected candidate genes. (B) Heatmap showing the expression profiles of the selected candidate genes. (C–D) LASSO cox regression identified eight signature genes that were most correlated with OS. These genes were used to construct a signature model. (E) The coefficient value of the selected eight signature genes. (F) Expression correlation analysis of the eight signature genes. (G) The expression profiles of the eight signature genes in tumor and cancer samples. (H) Mutation landscape of the eight signature genes in LUAD.