Research Paper Volume 13, Issue 6 pp 8720—8736

Parvalbumin interneuron-mediated neural disruption in an animal model of postintensive care syndrome: prevention by fluoxetine

Fluoxetine treatment attenuated PV deficit after combined stress. (A) Schematic timeline of the experimental procedure. (B–D) Representative images of PV interneurons in all subregions of the hippocampus. (E) Quantification of mean PV immunofluorescence in the hippocampus. Data are shown as mean ± SEM (n = 4), *P #P r = 100 μm. Con, control; LPS, lipopolysaccharide; Flu, fluoxetine; IF, immunofluorescence; LS, LPS + stress.

Figure 3. Fluoxetine treatment attenuated PV deficit after combined stress. (A) Schematic timeline of the experimental procedure. (B–D) Representative images of PV interneurons in all subregions of the hippocampus. (E) Quantification of mean PV immunofluorescence in the hippocampus. Data are shown as mean ± SEM (n = 4), *P < 0.05 vs control group, #P < 0.05 vs LS group, scale bar = 100 μm. Con, control; LPS, lipopolysaccharide; Flu, fluoxetine; IF, immunofluorescence; LS, LPS + stress.