Research Paper Volume 13, Issue 6 pp 8720—8736

Parvalbumin interneuron-mediated neural disruption in an animal model of postintensive care syndrome: prevention by fluoxetine

Altered hippocampal neural oscillations induced by combined stress were reversed by fluoxetine treatment. (A) Schematic timeline of the experimental procedure. (B) Representative images of local field potential in the CA1 of the hippocampus. (C) Quantification of local field potential in the CA1 of the hippocampus. (D) Quantification of average theta, alpha, beta, and gamma power in the CA1 of the hippocampus. (E) Theta oscillation was positively correlated with time spent with novel object. (F) Gamma oscillation was positively correlated with time spent with novel object. Data are shown as mean ± SEM (n = 6), *P #P

Figure 5. Altered hippocampal neural oscillations induced by combined stress were reversed by fluoxetine treatment. (A) Schematic timeline of the experimental procedure. (B) Representative images of local field potential in the CA1 of the hippocampus. (C) Quantification of local field potential in the CA1 of the hippocampus. (D) Quantification of average theta, alpha, beta, and gamma power in the CA1 of the hippocampus. (E) Theta oscillation was positively correlated with time spent with novel object. (F) Gamma oscillation was positively correlated with time spent with novel object. Data are shown as mean ± SEM (n = 6), *P < 0.05 vs control group, #P < 0.05 vs LS group. Con, control; LPS, lipopolysaccharide; Flu, fluoxetine; LS, LPS + stress; NORT, novel object recognition test.