Research Paper Volume 13, Issue 6 pp 8737—8761

Downregulation of FPN1 acts as a prognostic biomarker associated with immune infiltration in lung cancer

FPN1 mRNA expression in a variety of human cancers. (A) Human FPN1 expression in multiple types of cancer was determined using the TIMER database. (B) FPN1 expression was downregulated or upregulated in diverse cancers using the Oncomine database. (C) In the Garber Lung and Hou Lung datasets, the expression of FPN1 was decreased in LCLC, LUAD and LUSC tissues compared with normal tissues. (D) FPN1 was significantly downregulated in LUAD and LUSC in the UALCAN database. (E) FPN1 expression in lung cancer and adjacent normal tissues was statistically analyzed in the TCGA database. (F) TCGA database analysis and statistical analyses of the expression level of FPN1 were performed for 50 pairs of human lung cancer and adjacent paracancerous lung tissues. *p

Figure 1. FPN1 mRNA expression in a variety of human cancers. (A) Human FPN1 expression in multiple types of cancer was determined using the TIMER database. (B) FPN1 expression was downregulated or upregulated in diverse cancers using the Oncomine database. (C) In the Garber Lung and Hou Lung datasets, the expression of FPN1 was decreased in LCLC, LUAD and LUSC tissues compared with normal tissues. (D) FPN1 was significantly downregulated in LUAD and LUSC in the UALCAN database. (E) FPN1 expression in lung cancer and adjacent normal tissues was statistically analyzed in the TCGA database. (F) TCGA database analysis and statistical analyses of the expression level of FPN1 were performed for 50 pairs of human lung cancer and adjacent paracancerous lung tissues. *p<0.05, **p<0.01, ***p<0.01.