Research Paper Volume 13, Issue 7 pp 9582—9591

LCZ696 ameliorates lipopolysaccharide-induced endothelial injury

LCZ696 reduces LPS-induced expression of the cell adhesion molecules in HUVECs

Figure 6. LCZ696 reduces LPS-induced expression of the cell adhesion molecules in HUVECs. Cells were stimulated with LPS (1 μg/mL) in the presence or absence of LCZ696 (10, 20 μM) for 24 hours. (A). mRNA of VCAM-1; (B). mRNA of P-selectin; (C). Protein of VCAM-1; (D). Protein of p-selectin (***P < 0.005 vs. control group; ##, ###P < 0.01, 0.005 vs. LPS group).