Research Paper Volume 13, Issue 6 pp 8849—8864

HDAC11 inhibition disrupts porcine oocyte meiosis via regulating α-tubulin acetylation and histone modifications

JB-3-22 treatment increased the phosphorylation level of H3S10 and reduced the phosphorylation level of H3T3 in porcine oocytes. (A) Images of phosphorylated H3T3 in control and JB-3-22-treated oocytes at MI and MII stages. (B) Images of phosphorylated H3S10 in control and JB-3-22-treated oocytes at MI and MII stages. The results represent the mean ± standard deviation of three independent experiments. * P

Figure 5. JB-3-22 treatment increased the phosphorylation level of H3S10 and reduced the phosphorylation level of H3T3 in porcine oocytes. (A) Images of phosphorylated H3T3 in control and JB-3-22-treated oocytes at MI and MII stages. (B) Images of phosphorylated H3S10 in control and JB-3-22-treated oocytes at MI and MII stages. The results represent the mean ± standard deviation of three independent experiments. * P < 0.05 and ** P < 0.01. Scale bar, 100 μm.