Figure 4. Illustrates the hypothetical model of white matter pathological processes in early-onset Alzheimer’s disease (EOAD) and late-onset Alzheimer's disease (LOAD). Specifically, 3D schematic represents a magnified fiber bundle, green tubule and grid on the cross-section represent the axons and imaging voxels, respectively. (A) Represents the healthy fiber bundle in the aging population. EOAD (B) might undergo white mater disruption involved both the microstructural and macrostructural level, while the macrostructural degeneration dominates white matter loss in LOAD (C).