Research Paper Volume 13, Issue 6 pp 8944—8959

LncRNA-mRNA co-expression analysis discovered the diagnostic and prognostic biomarkers and potential therapeutic agents for myocardial infarction

LncRNA-mRNA network mining was used to identify MI diagnostic and prognostic biomarkers. (A) The distribution of diagnostic accuracy of each lncRNA, mRNA, lncRNA-mRNA pair in the network for MI; (B) The distribution of prognostic of each lncRNA, mRNA, lncRNA-mRNA pair in the network for MI; (C) The intersection of candidate RNA molecules and nodes with network degree, medium centrality, near centrality and eigenvector centrality of top 10% in the network; (D) Mean shortest path distribution of drugs to MI gene markers. (E) 2D structures of three potential MI drug molecules.

Figure 6. LncRNA-mRNA network mining was used to identify MI diagnostic and prognostic biomarkers. (A) The distribution of diagnostic accuracy of each lncRNA, mRNA, lncRNA-mRNA pair in the network for MI; (B) The distribution of prognostic of each lncRNA, mRNA, lncRNA-mRNA pair in the network for MI; (C) The intersection of candidate RNA molecules and nodes with network degree, medium centrality, near centrality and eigenvector centrality of top 10% in the network; (D) Mean shortest path distribution of drugs to MI gene markers. (E) 2D structures of three potential MI drug molecules.