COVID-19 Research Paper Volume 13, Issue 7 pp 9160—9185

TMBIM6, a potential virus target protein identified by integrated multiomics data analysis in SARS-CoV-2-infected host cells

Functional prediction of viral proteins in the blue module. (A–C) The paired associations of the top three viral proteins, ORF3a (A), PP1A (B) and ORF6 (C), with high-weight host proteins in the regulation predicted by GENIE3. The color depth represents the weight of the pairing between viral proteins and each host protein. (D–F) Enrichment of biological processes associated with host proteins regulated by the viral proteins ORF3a (D), PP1A (E) and ORF6 (F).

Figure 3. Functional prediction of viral proteins in the blue module. (A–C) The paired associations of the top three viral proteins, ORF3a (A), PP1A (B) and ORF6 (C), with high-weight host proteins in the regulation predicted by GENIE3. The color depth represents the weight of the pairing between viral proteins and each host protein. (D–F) Enrichment of biological processes associated with host proteins regulated by the viral proteins ORF3a (D), PP1A (E) and ORF6 (F).