COVID-19 Research Paper Volume 13, Issue 7 pp 9160—9185

TMBIM6, a potential virus target protein identified by integrated multiomics data analysis in SARS-CoV-2-infected host cells

Identification of the host protein TMBIM6 as a potential target for viral pathogenesis. (A) Top 10 coexpression relationships of SARS-COV-2 proteins, including PP1A, S, ORF3a, ORF6, ORF9b and N, and host proteins from the blue module. TMBIM6 was found to be coexpressed with these six viral proteins. (B–D) The expression of TMBIM6 at different times based on multiomics data from SARS-CoV-2-infected cells. n = 3, *P value **P value E) Heatmap of expression clustering for proteins from the translational data. The cluster with an expression pattern similar to TMBIM6 was selected for the next step of analysis. (F) Enrichment analysis of biological processes of proteins from the selected cluster with P value

Figure 4. Identification of the host protein TMBIM6 as a potential target for viral pathogenesis. (A) Top 10 coexpression relationships of SARS-COV-2 proteins, including PP1A, S, ORF3a, ORF6, ORF9b and N, and host proteins from the blue module. TMBIM6 was found to be coexpressed with these six viral proteins. (B–D) The expression of TMBIM6 at different times based on multiomics data from SARS-CoV-2-infected cells. n = 3, *P value < 0.05, **P value < 0.001. (E) Heatmap of expression clustering for proteins from the translational data. The cluster with an expression pattern similar to TMBIM6 was selected for the next step of analysis. (F) Enrichment analysis of biological processes of proteins from the selected cluster with P value < 0.05.