COVID-19 Research Paper Volume 13, Issue 7 pp 9160—9185

TMBIM6, a potential virus target protein identified by integrated multiomics data analysis in SARS-CoV-2-infected host cells

A proposed working model for the apoptosis of host cells infected with SARS-CoV-2. Possible mechanisms of host cell apoptosis induced by SARS-CoV-2 through translational inhibition of TMBIM6. TMBIM6 is a multifunctional protein that can inhibit the activation of BAX, ROS production and Ca2+ release from the ER. Upon SARS-CoV-2 infection, downregulated TMBIM6 promotes the release of Ca2+ and ROS accumulation in mitochondria, which leads to the release of proapoptotic factors. In addition, downregulation of TMBIM6 relieves its inhibition of BAX activation, thus leading to host cell apoptosis.

Figure 6. A proposed working model for the apoptosis of host cells infected with SARS-CoV-2. Possible mechanisms of host cell apoptosis induced by SARS-CoV-2 through translational inhibition of TMBIM6. TMBIM6 is a multifunctional protein that can inhibit the activation of BAX, ROS production and Ca2+ release from the ER. Upon SARS-CoV-2 infection, downregulated TMBIM6 promotes the release of Ca2+ and ROS accumulation in mitochondria, which leads to the release of proapoptotic factors. In addition, downregulation of TMBIM6 relieves its inhibition of BAX activation, thus leading to host cell apoptosis.