Research Paper Volume 13, Issue 8 pp 11061—11082

microRNA-363-3p reduces endothelial cell inflammatory responses in coronary heart disease via inactivation of the NOX4-dependent p38 MAPK axis

A schematic for the function and mechanism of miR-363-3p in CHD. miR-363-3p targets NOX4 and disrupts the p38 MAPK/ signaling pathway, which consequently reduces the apoptosis of CAECs, oxidative stress injury and the expression of inflammatory factors in CAECs, thus protecting CAECs against CHD.

Figure 11. A schematic for the function and mechanism of miR-363-3p in CHD. miR-363-3p targets NOX4 and disrupts the p38 MAPK/ signaling pathway, which consequently reduces the apoptosis of CAECs, oxidative stress injury and the expression of inflammatory factors in CAECs, thus protecting CAECs against CHD.