Research Paper Volume 13, Issue 8 pp 11061—11082

microRNA-363-3p reduces endothelial cell inflammatory responses in coronary heart disease via inactivation of the NOX4-dependent p38 MAPK axis

miR-363-3p attenuates apoptosis of CAECs by targeting NOX4. (A) Hoechst 33258 staining and quantification of apoptosis in CAECs (scale bar = 25 μm); (B) flow cytometry and quantification of apoptosis in CAECs; * p NOX4, NADPH oxidase 4; NC, negative control.

Figure 9. miR-363-3p attenuates apoptosis of CAECs by targeting NOX4. (A) Hoechst 33258 staining and quantification of apoptosis in CAECs (scale bar = 25 μm); (B) flow cytometry and quantification of apoptosis in CAECs; * p < 0.05 vs. the blank group; # p < 0.05 vs. the miR-363-3p inhibitor group; the data were analyzed by one-way ANOVA with Tukey's post hoc test; n = 3; CAECs, coronary artery endothelial cells; miR, microRNA; NOX4, NADPH oxidase 4; NC, negative control.