Research Paper Volume 13, Issue 6 pp 8078—8094

Flotillin-2 promotes cell proliferation via activating the c-Myc/BCAT1 axis by suppressing miR-33b-5p in nasopharyngeal carcinoma

FLOT2 positively regulates and predicts poor prognosis in NPC. (A, B) qPCR and western blot assays indicating the level of BCAT1 mRNA and protein in 5-8F-shFLOT2, 6-10B-BCAT1 and control cells. (C) The representative IHC pictures indicating the co-expression patterns of FLOT2 and BCAT1 in patients with NPC (magnification, 200×). (D) Spearman correlation analysis indicating the positive correlation between FLOT2 and BCAT1 in NPC. (E) Kaplan-Meier survival analysis showing the level of FLOT2 and BCAT1 negatively associates with overall survival outcome in NPC.

Figure 1. FLOT2 positively regulates and predicts poor prognosis in NPC. (A, B) qPCR and western blot assays indicating the level of BCAT1 mRNA and protein in 5-8F-shFLOT2, 6-10B-BCAT1 and control cells. (C) The representative IHC pictures indicating the co-expression patterns of FLOT2 and BCAT1 in patients with NPC (magnification, 200×). (D) Spearman correlation analysis indicating the positive correlation between FLOT2 and BCAT1 in NPC. (E) Kaplan-Meier survival analysis showing the level of FLOT2 and BCAT1 negatively associates with overall survival outcome in NPC.