Research Paper Volume 13, Issue 7 pp 9748—9765

Long non-coding RNA DPP10-AS1 exerts anti-tumor effects on colon cancer via the upregulation of ADCY1 by regulating microRNA-127-3p

Potential molecular mechanism of the DPP10-AS1/miR-127-3p/ADCY1 axis in CCSCs. In CCSCs, upregulation of DPP10-AS1 inhibits the expression of miR-127-3p to increase ADCY1 expression, thereby inhibiting CCSC sphere and colony formation, proliferation, migration and invasion and promoting the apoptosis.

Figure 8. Potential molecular mechanism of the DPP10-AS1/miR-127-3p/ADCY1 axis in CCSCs. In CCSCs, upregulation of DPP10-AS1 inhibits the expression of miR-127-3p to increase ADCY1 expression, thereby inhibiting CCSC sphere and colony formation, proliferation, migration and invasion and promoting the apoptosis.