Research Paper Volume 13, Issue 7 pp 9801—9819

Sex-specific differences of humoral immunity and transcriptome diversification in older adults vaccinated with inactivated quadrivalent influenza vaccines

Protein-protein interaction (PPI) network analysis of two female-bias hub genes IFITM3 (A) and C1QA (B). The hub gene IFITM3 was involved in type I interferon signaling pathway, while gene C1QA contributed to complement activation of classical pathway.

Figure 5. Protein-protein interaction (PPI) network analysis of two female-bias hub genes IFITM3 (A) and C1QA (B). The hub gene IFITM3 was involved in type I interferon signaling pathway, while gene C1QA contributed to complement activation of classical pathway.