Research Paper Volume 13, Issue 7 pp 9838—9858

lncRNA SNHG4 modulates colorectal cancer cell cycle and cell proliferation through regulating miR-590-3p/CDK1 axis

Expression of long noncoding RNA SNHG4 (lncRNA SNHG4) based on publicly available and experimental data. (A) The expression of SNHG4 in colorectal and normal noncancerous tissues according to the publicly available microarray expression profiles GSE8671, GSE74602, and TCGA Colon and Rectal Cancer (TCGA-CRC). (B) The expression of SNHG4 in colorectal cancer (CRC) M0-stage (nonmetastatic) and M1-stage (lymphatic or distal metastatic) tissues according to TCGA-CRC data. (C) The expression of SNHG4 in CRC microsatellite instability (MSI) and microsatellite stable (MSS) tissues according to TCGA-CRC data. (D) The expression of SNHG4 was determined in 12 CRC and normal noncancerous tissues by real-time PCR. (E) The expression of SNHG4 was determined in one normal fetal colon cell line (FHC) and five CRC cell lines (HCT8, LoVo, HCT116, SW620, and HT29) by real-time PCR. *P **P

Figure 1. Expression of long noncoding RNA SNHG4 (lncRNA SNHG4) based on publicly available and experimental data. (A) The expression of SNHG4 in colorectal and normal noncancerous tissues according to the publicly available microarray expression profiles GSE8671, GSE74602, and TCGA Colon and Rectal Cancer (TCGA-CRC). (B) The expression of SNHG4 in colorectal cancer (CRC) M0-stage (nonmetastatic) and M1-stage (lymphatic or distal metastatic) tissues according to TCGA-CRC data. (C) The expression of SNHG4 in CRC microsatellite instability (MSI) and microsatellite stable (MSS) tissues according to TCGA-CRC data. (D) The expression of SNHG4 was determined in 12 CRC and normal noncancerous tissues by real-time PCR. (E) The expression of SNHG4 was determined in one normal fetal colon cell line (FHC) and five CRC cell lines (HCT8, LoVo, HCT116, SW620, and HT29) by real-time PCR. *P < 0.05, **P < 0.01, compared to FHC cells.