Research Paper Volume 13, Issue 7 pp 9900—9910

LncRNA MNX1-AS1 drives aggressive laryngeal squamous cell carcinoma progression and serves as a ceRNA to target FoxM1 by sponging microRNA-370

MNX1-AS1 exerts tumor-promoting role in LSCC by regulating the miR-370/FoxM1 axis. (A, B) The expression of FoxM1 on mRNA and protein levels was examined in TU212 cells transfected with sh-NC, sh-MNX1-AS1, and sh-MNX1-AS1+ anti-miR-370. (C) The mRNA expression of FoxM1 was examined in LSCC tissues and adjacent normal tissues. (D) Correlation between FoxM1 and miR-370 expression in LSCC tissues was analyzed by Pearson’s correlation analysis. (E) Correlation between MNX1-AS1 and FoxM1 expression in LSCC tissues was analyzed by Pearson’s correlation analysis. (F–I) Cell proliferation, colony formation, migration and invasion were detected in TU212 cells transfected with sh-NC, sh-MNX1-AS1, and sh-MNX1-AS1+ anti-miR-370 and sh-MNX1-AS1+FoxM1. *P **P

Figure 5. MNX1-AS1 exerts tumor-promoting role in LSCC by regulating the miR-370/FoxM1 axis. (A, B) The expression of FoxM1 on mRNA and protein levels was examined in TU212 cells transfected with sh-NC, sh-MNX1-AS1, and sh-MNX1-AS1+ anti-miR-370. (C) The mRNA expression of FoxM1 was examined in LSCC tissues and adjacent normal tissues. (D) Correlation between FoxM1 and miR-370 expression in LSCC tissues was analyzed by Pearson’s correlation analysis. (E) Correlation between MNX1-AS1 and FoxM1 expression in LSCC tissues was analyzed by Pearson’s correlation analysis. (F–I) Cell proliferation, colony formation, migration and invasion were detected in TU212 cells transfected with sh-NC, sh-MNX1-AS1, and sh-MNX1-AS1+ anti-miR-370 and sh-MNX1-AS1+FoxM1. *P < 0.05; **P < 0.01.