Research Paper Volume 13, Issue 7 pp 9911—9926

Exosomes derived from microRNA-512-5p-transfected bone mesenchymal stem cells inhibit glioblastoma progression by targeting JAG1

BMSC-exosomal miR-512-5p inhibits GBM cell proliferation and causes cell cycle arrest. (A) Cell proliferation activity as examined by EdU assays. (200 ×) (B) Cell proliferation activity as examined by colony formation assays. (C) Analysis of cell cycle by flow cytometry. (D) G1-arrest-relevant cell cycle regulators determined by western blotting assays. Data are represented as the mean ± standard deviation of three independent experiments. *p **p t-test, compared to the Control group.

Figure 6. BMSC-exosomal miR-512-5p inhibits GBM cell proliferation and causes cell cycle arrest. (A) Cell proliferation activity as examined by EdU assays. (200 ×) (B) Cell proliferation activity as examined by colony formation assays. (C) Analysis of cell cycle by flow cytometry. (D) G1-arrest-relevant cell cycle regulators determined by western blotting assays. Data are represented as the mean ± standard deviation of three independent experiments. *p < 0.05, **p < 0.01, Student's t-test, compared to the Control group.