Research Paper Volume 13, Issue 7 pp 9911—9926

Exosomes derived from microRNA-512-5p-transfected bone mesenchymal stem cells inhibit glioblastoma progression by targeting JAG1

Exosomes derived from MicroRNA-512-5p transfected bone mesenchymal stem cell inhibit glioblastoma progression by targeting JAG1. BMSC-exosomal miR-512-5p inhibited the expression of JAG1 in GBM, and suppressed cell proliferation and G1-S phase cell cycle by inhibiting the expression of CDK4, CDK6 and Cyclin D1.

Figure 8. Exosomes derived from MicroRNA-512-5p transfected bone mesenchymal stem cell inhibit glioblastoma progression by targeting JAG1. BMSC-exosomal miR-512-5p inhibited the expression of JAG1 in GBM, and suppressed cell proliferation and G1-S phase cell cycle by inhibiting the expression of CDK4, CDK6 and Cyclin D1.