Research Paper Volume 13, Issue 6 pp 9028—9042

Effect of bovine bone collagen oligopeptides on wound healing in mice

Effect of BCOP on wounds histology (HE staining) in mice. The incision site of NC showed irregular arrangement of collagen bundles, loose accumulation, and only moderate fibroblasts in the wound. BCOP-treated wound sites showed dense and compact collagen bundles with more fibroblasts, increased angiogenesis, and continuous epithelialization, reflecting faster wound healing compared to vehicle-treated groups. Magnification, × 200; NC, normal control group; BCOP-L, 0.75 g/kg bovine bone collagen oligopeptides group; BCOP-M, 1.50 g/kg bovine bone collagen oligopeptides group; BCOP-H, 3.00 g/kg bovine bone collagen oligopeptides group.

Figure 3. Effect of BCOP on wounds histology (HE staining) in mice. The incision site of NC showed irregular arrangement of collagen bundles, loose accumulation, and only moderate fibroblasts in the wound. BCOP-treated wound sites showed dense and compact collagen bundles with more fibroblasts, increased angiogenesis, and continuous epithelialization, reflecting faster wound healing compared to vehicle-treated groups. Magnification, × 200; NC, normal control group; BCOP-L, 0.75 g/kg bovine bone collagen oligopeptides group; BCOP-M, 1.50 g/kg bovine bone collagen oligopeptides group; BCOP-H, 3.00 g/kg bovine bone collagen oligopeptides group.