Research Paper Volume 13, Issue 5 pp 6420—6441

Aging and pathological aging signatures of the brain: through the focusing lens of SIRT6

Selected hubs of brain signature categories. (A) Venn diagram for SIRT6 target genes differentially expressed also in Aging, Alzheimer's disease (AD), Parkinson's disease (PD), or Aged samples under Calorie Restriction (CR) datasets. Numbers represent the number of genes in each section, which change in at least one dataset of a certain group of datasets. (B) A scheme of genes analysis pipeline. The lower panels note the Table/Figure in which the results can be found for each step. DE gene – differentially expressed gene; ND and REV Scores – Neurodegeneration and Reversibility Scores; TF – transcription factor. Figure was created with BioRender.com. (C) Manually chosen TFs (out of the top TFs per signature category) and their target genes represent the hubs of brain signature categories.

Figure 3. Selected hubs of brain signature categories. (A) Venn diagram for SIRT6 target genes differentially expressed also in Aging, Alzheimer's disease (AD), Parkinson's disease (PD), or Aged samples under Calorie Restriction (CR) datasets. Numbers represent the number of genes in each section, which change in at least one dataset of a certain group of datasets. (B) A scheme of genes analysis pipeline. The lower panels note the Table/Figure in which the results can be found for each step. DE gene – differentially expressed gene; ND and REV Scores – Neurodegeneration and Reversibility Scores; TF – transcription factor. Figure was created with BioRender.com. (C) Manually chosen TFs (out of the top TFs per signature category) and their target genes represent the hubs of brain signature categories.