Research Paper Volume 13, Issue 7 pp 10034—10057

A five-m6A regulatory gene signature is a prognostic biomarker in lung adenocarcinoma patients

Development of a five-gene prognostic signature. (A) The forest plots show association between expression levels of seventeen m6A regulatory genes and OS of LADC patients as determined by the univariate Cox regression model. (B) LASSO coefficients profiles of the six potentially prognostic m6A regulatory genes. (C) The coefficients of five prognostic m6A regulatory genes based on lambda.min using 10-fold cross validation. (D) The co-efficient distributions of the five prognostic m6A regulatory genes. (E) The distribution of risk scores in the training set LADC patients from the TCGA database. (F) The distribution of risk scores of the training set TCGA-LADC patients relative to their OS status.

Figure 2. Development of a five-gene prognostic signature. (A) The forest plots show association between expression levels of seventeen m6A regulatory genes and OS of LADC patients as determined by the univariate Cox regression model. (B) LASSO coefficients profiles of the six potentially prognostic m6A regulatory genes. (C) The coefficients of five prognostic m6A regulatory genes based on lambda.min using 10-fold cross validation. (D) The co-efficient distributions of the five prognostic m6A regulatory genes. (E) The distribution of risk scores in the training set LADC patients from the TCGA database. (F) The distribution of risk scores of the training set TCGA-LADC patients relative to their OS status.