Research Paper Volume 13, Issue 7 pp 10058—10074

Gut microbiota from mice with cerebral ischemia-reperfusion injury affects the brain in healthy mice

Effect of BCCAO microbiota on mice behavior. (A) Time spent in the center (left), corner (middle), and periphery (right) of the open field test. (B) The nest-building scores of micecontrol and miceBCCAO. (C) The latency in the training and testing phases for micecontrol and miceBCCAO in the Morris water maze test. (D) The preferential index (%) after 1 hour (left) and 24 hours (right) of training in the testing phase of the novel object recognition test. * denotes P P P t-tests or a two-way repeated-measures ANOVA with post-hoc Tukey multiple comparisons test. All values are expressed as means ± S.D, n=15.

Figure 4. Effect of BCCAO microbiota on mice behavior. (A) Time spent in the center (left), corner (middle), and periphery (right) of the open field test. (B) The nest-building scores of micecontrol and miceBCCAO. (C) The latency in the training and testing phases for micecontrol and miceBCCAO in the Morris water maze test. (D) The preferential index (%) after 1 hour (left) and 24 hours (right) of training in the testing phase of the novel object recognition test. * denotes P < 0.05, ** denotes P < 0.01 and *** denotes P < 0.001 compared with control mice using unpaired Student`s t-tests or a two-way repeated-measures ANOVA with post-hoc Tukey multiple comparisons test. All values are expressed as means ± S.D, n=15.