Figure 5. A schematic of the feedback regulation mechanism of the TCORE circuit integrating the POAH. TCORE feedback sensory signals come from thermoreceptors in the skin. Then, the signals are transmitted to the DH. Cutaneous thermoreceptor signals from the DH to the POAH that drive feedforward thermoregulatory responses are integrated with a variety of currently unidentified inputs in the LPB of the pons. TCORE: constant body core temperature; POAH: preoptic and anterior hypothalamic region; DH: dorsal horn; LPB: lateral parabrachial nucleus.