Research Paper Volume 13, Issue 7 pp 10175—10186

Regulation of PINX1 expression ameliorates lipopolysaccharide-induced lung injury and alleviates cell senescence during the convalescent phase through affecting the telomerase activity

TERT overexpression, PINX1 silencing, and PINX1 overexpression presented different effects on pathological changes of lung tissue on D3 and D14 in LPS-induced lung injury rats. The histopathological changes in lung tissues on (A) D3 and (B) D14 were evaluated using H&E staining. *P***P#P##P###PΔΔP

Figure 2. TERT overexpression, PINX1 silencing, and PINX1 overexpression presented different effects on pathological changes of lung tissue on D3 and D14 in LPS-induced lung injury rats. The histopathological changes in lung tissues on (A) D3 and (B) D14 were evaluated using H&E staining. *P<0.05, ***P<0.001 vs. Control; #P<0.05, ##P<0.01, ###P<0.001 vs. Model+vector; ΔΔP<0.01 vs. Model+OE-PINX1.