Research Paper Volume 13, Issue 7 pp 10175—10186

Regulation of PINX1 expression ameliorates lipopolysaccharide-induced lung injury and alleviates cell senescence during the convalescent phase through affecting the telomerase activity

class="figure-viewer-img"

Figure 2. TERT overexpression, PINX1 silencing, and PINX1 overexpression presented different effects on pathological changes of lung tissue on D3 and D14 in LPS-induced lung injury rats. The histopathological changes in lung tissues on (A) D3 and (B) D14 were evaluated using H&E staining. *P<0.05, ***P<0.001 vs. Control; #P<0.05, ##P<0.01, ###P<0.001 vs. Model+vector; ΔΔP<0.01 vs. Model+OE-PINX1.