Research Paper Volume 13, Issue 7 pp 10175—10186

Regulation of PINX1 expression ameliorates lipopolysaccharide-induced lung injury and alleviates cell senescence during the convalescent phase through affecting the telomerase activity

TERT overexpression or PINX1 silencing aggravated apoptosis on D3 while promoted the recovery of apoptosis on D14, whereas PINX1 overexpression presented the opposite effects. Cell apoptosis on (A) D3 and (B) D14 was detected using TUNEL staining. ***P#P###PΔPΔΔΔP

Figure 4. TERT overexpression or PINX1 silencing aggravated apoptosis on D3 while promoted the recovery of apoptosis on D14, whereas PINX1 overexpression presented the opposite effects. Cell apoptosis on (A) D3 and (B) D14 was detected using TUNEL staining. ***P<0.001 vs. Control; #P<0.05, ###P<0.001 vs. Model+vector; ΔP<0.05, ΔΔΔP<0.001 vs. Model+OE-PINX1.