Research Paper Volume 13, Issue 8 pp 11188—11206

Silencing long non-coding RNA MIAT ameliorates myocardial dysfunction induced by myocardial infarction via MIAT/miR-10a-5p/EGR2 axis

Regulatory mechanism of MIAT in MI mice with the involvement of miR-10a-5p and EGR2. Inhibition of the MIAT induces miR-10a-5p-dependent inhibition of EGR2 and reduces the production of cleaved caspase-3, ultimately suppressing the apoptosis of cardiomyocytes.

Figure 6. Regulatory mechanism of MIAT in MI mice with the involvement of miR-10a-5p and EGR2. Inhibition of the MIAT induces miR-10a-5p-dependent inhibition of EGR2 and reduces the production of cleaved caspase-3, ultimately suppressing the apoptosis of cardiomyocytes.