Research Paper Volume 13, Issue 10 pp 13535—13547

FAM134B-mediated endoplasmic reticulum autophagy protects against sepsis myocardial injury in mice

The expression of FAM134B in the mice with sepsis myocardial injury. (A) Mice were divided into four groups: Sham, Sep, Sep + Rap group, and Sep + 3-MA group, and the myocardial histomorphology was examined by H&E staining. (B) Myocardial apoptosis was identified by TUNEL analysis. (C, D) Protein expressions of LC3-II/I (red fluorescence) and FAM134B (green fluorescence) in the myocardial tissues were examined by immunofluorescence and western blot. Data are shown as mean ± SD. *P

Figure 1. The expression of FAM134B in the mice with sepsis myocardial injury. (A) Mice were divided into four groups: Sham, Sep, Sep + Rap group, and Sep + 3-MA group, and the myocardial histomorphology was examined by H&E staining. (B) Myocardial apoptosis was identified by TUNEL analysis. (C, D) Protein expressions of LC3-II/I (red fluorescence) and FAM134B (green fluorescence) in the myocardial tissues were examined by immunofluorescence and western blot. Data are shown as mean ± SD. *P<0.05, **P<0.01 and ***P<0.001. Sep: Sepsis. SD: standard deviation.