Research Paper Volume 13, Issue 10 pp 13535—13547

FAM134B-mediated endoplasmic reticulum autophagy protects against sepsis myocardial injury in mice

The effect of FAM134B on the expressions of autophagy-related proteins. (A, B) Cardiomyocytes were transfected with oeNC, oeFAM143B, siNC, siFAM134B, and then treated with LPS. The protein expressions of LC3-II/I, IRE1α, GRP78, Beclin-1, and LAMP2 were detected by western blot analysis. Data are shown as mean ± SD. *P

Figure 6. The effect of FAM134B on the expressions of autophagy-related proteins. (A, B) Cardiomyocytes were transfected with oeNC, oeFAM143B, siNC, siFAM134B, and then treated with LPS. The protein expressions of LC3-II/I, IRE1α, GRP78, Beclin-1, and LAMP2 were detected by western blot analysis. Data are shown as mean ± SD. *P<0.05, **P<0.01 and ***P<0.001. SD: standard deviation.