Research Paper Volume 13, Issue 8 pp 11207—11217

Panax notoginseng protects the rat brain function from traumatic brain injury by inhibiting autophagy via mammalian targeting of rapamycin

Compared with the Model group and Rapamycin group, autophagy protein was significantly decreased, and brain injury and brain function were significantly improved in the PI3K inhibitor group. (A) HE staining, Nissl staining and transmission electron microscopy of brain tissue. (B) The neural function defect score at 12h, 24h and 72h. (C) mTOR, p-mTOR, P62, Beclin 1, LC3I and LC3II by Western-blotting, n=6.

Figure 2. Compared with the Model group and Rapamycin group, autophagy protein was significantly decreased, and brain injury and brain function were significantly improved in the PI3K inhibitor group. (A) HE staining, Nissl staining and transmission electron microscopy of brain tissue. (B) The neural function defect score at 12h, 24h and 72h. (C) mTOR, p-mTOR, P62, Beclin 1, LC3I and LC3II by Western-blotting, n=6.