Research Paper Volume 13, Issue 7 pp 10354—10368

Identification of GSPT1 as prognostic biomarker and promoter of malignant colon cancer cell phenotypes via the GSK-3β/CyclinD1 pathway

GSPT1 knockdown inhibits colon cancer growth in vitro and vivo. (A) Colony formation assay showed colonies numbers in the GSPT1 knockdown group were lower than those in NC group. (B) The cell invasion ability was detected by transwell assay. (C) Tumor volume of GSPT1 knockdown group was lower than NC group. (D) Tumor weight of the GSPT1 silence group was lower than NC group.

Figure 4. GSPT1 knockdown inhibits colon cancer growth in vitro and vivo. (A) Colony formation assay showed colonies numbers in the GSPT1 knockdown group were lower than those in NC group. (B) The cell invasion ability was detected by transwell assay. (C) Tumor volume of GSPT1 knockdown group was lower than NC group. (D) Tumor weight of the GSPT1 silence group was lower than NC group.