Research Paper Volume 13, Issue 7 pp 10431—10449

miR-224 aggravates cancer-associated fibroblast-induced progression of non-small cell lung cancer by modulating a positive loop of the SIRT3/AMPK/mTOR/HIF-1α axis

The sketch map of the regulatory loop of the miR-224-SIRT3-AMPK-mTOR-HIF-1α axis. miR-224 targeted SIRT3 and inhibited AMPK, followed by up-regulation of mTOR-HIF-1α. A higher level of HIF-1α then enhanced the transcription of miR-224 as well as the other genes in promoting cell growth, angiogenesis and metastasis of NSCLC cells.

Figure 8. The sketch map of the regulatory loop of the miR-224-SIRT3-AMPK-mTOR-HIF-1α axis. miR-224 targeted SIRT3 and inhibited AMPK, followed by up-regulation of mTOR-HIF-1α. A higher level of HIF-1α then enhanced the transcription of miR-224 as well as the other genes in promoting cell growth, angiogenesis and metastasis of NSCLC cells.