Figure 2. 6Prognosis analysis of tumor mutation burden (TMB) and correlation analysis with clinical risk features. (A) Patients with higher TMB had better overall survival (OS, P = 0.0014). (B) There was no association of TMB with disease-free survival (DFS, P = 0.51). (C, D) High TMB level was negatively correlated with tumor stage and pathological stage, with P = 0.035 and 0.02, respectively. Vertical and horizontal axes represent TMB value and different stages, respectively. (E–G) Significant difference was observed in the AJCC-T stages (P = 0.027), while no significant differences were observed in the AJCC-N and AJCC-M stages (P > 0.05). TMB, tumor mutation burden. Vertical and horizontal axes represent TMB value and different stages, respectively. TMB, tumor mutation burden; OS, overall survival; DFI, disease-free interval.