Research Paper Volume 13, Issue 8 pp 11257—11280

Prognostic analysis of tumor mutation burden and immune infiltration in hepatocellular carcinoma based on TCGA data

6Prognosis analysis of tumor mutation burden (TMB) and correlation analysis with clinical risk features. (A) Patients with higher TMB had better overall survival (OS, P = 0.0014). (B) There was no association of TMB with disease-free survival (DFS, P = 0.51). (C, D) High TMB level was negatively correlated with tumor stage and pathological stage, with P = 0.035 and 0.02, respectively. Vertical and horizontal axes represent TMB value and different stages, respectively. (E–G) Significant difference was observed in the AJCC-T stages (P = 0.027), while no significant differences were observed in the AJCC-N and AJCC-M stages (P > 0.05). TMB, tumor mutation burden. Vertical and horizontal axes represent TMB value and different stages, respectively. TMB, tumor mutation burden; OS, overall survival; DFI, disease-free interval.

Figure 2. 6Prognosis analysis of tumor mutation burden (TMB) and correlation analysis with clinical risk features. (A) Patients with higher TMB had better overall survival (OS, P = 0.0014). (B) There was no association of TMB with disease-free survival (DFS, P = 0.51). (C, D) High TMB level was negatively correlated with tumor stage and pathological stage, with P = 0.035 and 0.02, respectively. Vertical and horizontal axes represent TMB value and different stages, respectively. (EG) Significant difference was observed in the AJCC-T stages (P = 0.027), while no significant differences were observed in the AJCC-N and AJCC-M stages (P > 0.05). TMB, tumor mutation burden. Vertical and horizontal axes represent TMB value and different stages, respectively. TMB, tumor mutation burden; OS, overall survival; DFI, disease-free interval.