Research Paper Volume 13, Issue 8 pp 11281—11295

Secreted frizzled-related protein 3 was genetically and functionally associated with developmental dysplasia of the hip

Tissue expression of FRZB in patients and controls. (A) DDH patients were found to have significantly higher expression of the FRZB in the articular cartilage and ligament as compared with the controls (2.43 ± 1.65 vs 4.05 ± 1.89, p = 0.002 for articular cartilage; 2.46 ±1.68 vs. 3.85 ± 2.73, p = 0.007 for joint ligament). (B) Immunofluorescent assay of FRZB (red) expression and nucleus (blue) in the cartilage and ligament tissues in different groups of patients observed under confocal microscopy.

Figure 1. Tissue expression of FRZB in patients and controls. (A) DDH patients were found to have significantly higher expression of the FRZB in the articular cartilage and ligament as compared with the controls (2.43 ± 1.65 vs 4.05 ± 1.89, p = 0.002 for articular cartilage; 2.46 ±1.68 vs. 3.85 ± 2.73, p = 0.007 for joint ligament). (B) Immunofluorescent assay of FRZB (red) expression and nucleus (blue) in the cartilage and ligament tissues in different groups of patients observed under confocal microscopy.