Research Paper Volume 13, Issue 8 pp 11281—11295

Secreted frizzled-related protein 3 was genetically and functionally associated with developmental dysplasia of the hip

FRZB blocked Wnt signaling and inhibited the catabolic activities and hypertrophy in the induced chondrogenic tissues. (A) Expression level of Wnt pathway markers (β-catenin, WNT3A and WNT8A) for BMSCs in different treatment groups (n=6 for each) (B) Expression level of catabolic markers (MMP9, MMP13 and ADAMTS5) in different treatment groups (n=6 for each). (C) Expression level of hypertrophy and osteogenesis markers (COL10A1, RUNX2 and OCN) for BMSCs in different treatment groups (n=6 for each). *P

Figure 3. FRZB blocked Wnt signaling and inhibited the catabolic activities and hypertrophy in the induced chondrogenic tissues. (A) Expression level of Wnt pathway markers (β-catenin, WNT3A and WNT8A) for BMSCs in different treatment groups (n=6 for each) (B) Expression level of catabolic markers (MMP9, MMP13 and ADAMTS5) in different treatment groups (n=6 for each). (C) Expression level of hypertrophy and osteogenesis markers (COL10A1, RUNX2 and OCN) for BMSCs in different treatment groups (n=6 for each). *P < 0.05 between control group and other groups. Data are presented as averages ± SD. One-way analysis of variance (ANOVA) with post-hoc Tukey’s B test was applied.