Research Paper Volume 13, Issue 8 pp 11363—11380

Melatonin attenuates smoking-induced atherosclerosis by activating the Nrf2 pathway via NLRP3 inflammasomes in endothelial cells

Melatonin reduced intimal hyperplasia of rat carotid artery after balloon injury with cigarette smoking. (A, B) H&E and VVG stained sections of carotid arteries of each group. Intima and media were labeled with "I" and "M" respectively. (C) Quantitative graphs of Intima to Media (I/M) ratio and intimal area. **p . The data are represented as mean ± SD (n = 3).

Figure 7. Melatonin reduced intimal hyperplasia of rat carotid artery after balloon injury with cigarette smoking. (A, B) H&E and VVG stained sections of carotid arteries of each group. Intima and media were labeled with "I" and "M" respectively. (C) Quantitative graphs of Intima to Media (I/M) ratio and intimal area. **p < 0.01. The data are represented as mean ± SD (n = 3).